PhD Candidate in Molecular Modelling / PhD Candidate in Molecular Modelling

PhD Position in Molecular Modelling

100%, Zurich, fixed-term

We are excited to announce a PhD position focusing on the molecular modeling of intrinsically disordered proteins constrained by EPR, cross-linking, and NMR techniques. This project will specifically target proteins in dispersed and liquid-liquid phase-separated states. The challenge lies in addressing the conformational distributions of these proteins, a task that requires advanced spectroscopic and modeling methods. Our goal is to combine experimental data from multiple ongoing projects with coarse-grained molecular modeling to reveal critical insights into these conformational distributions.

Project Background

The primary objective for the chosen candidate will be to design, implement, and utilize a coarse-grained representation for intrinsically disordered proteins (IDPs). The resulting model will incorporate both artificial and experimental EPR restraints, facilitating EPR-constrained molecular dynamics calculations that will help to establish experimentally-guided conformational ensembles for biologically significant IDPs.

Job Description

This four-year project, funded by ETH Zurich, will be supervised by Dr. Maxim Yulikov from the Jeschke group and in collaboration with Dr. Andreas Vitalis from the Caflisch group. The project will benefit from the experimental input of various ongoing structural biology initiatives within the Jeschke group at ETH. Candidates with prior experience in setting up classical molecular simulations will have a significant advantage. We seek individuals who possess strong knowledge in physical chemistry and its mathematical foundations. Familiarity with programming and excellent communication skills are also beneficial. Success in this project will depend on the ability to balance independent work with collaborative efforts involving EPR specialists, simulation experts, and molecular biologists.

Profile

We expect candidates to possess the following qualifications:

• A recently obtained master's degree in physics, physical chemistry, or a related field with a strong emphasis on physical chemistry and computational methods.
• Proficiency in at least one programming language.
• Fluency in English as the working language.
• Strong interpersonal skills for both independent and team collaboration.
• A genuine interest in molecular modeling and scientific research.
• Experience in setting up classical molecular simulations is advantageous.

Workplace

The position is based at the renowned ETH Zurich, a leading institution committed to excellence in research and education.

What We Offer

• Opportunities for a meaningful career within ETH Zurich, a university dedicated to fostering professional growth and driving positive societal change.
• {{Active commitment to sustainability and climate neutrality in our operations.}}
• A variety of benefits, including public transport season tickets, car-sharing options, access to a broad range of sports offered by ASVZ, childcare services, and attractive pension benefits.

Curious? So Are We!

Apply online using the form below.

For any inquiries, you may visit us in person at office HCI F231. Please note that two recommendation letters from previous research project or university course supervisors will be requested during the evaluation process. The start date for this position is no later than August 1, 2025. We encourage interested candidates to apply without delay, as the position will close once a suitable candidate has been identified.

For questions regarding the position, please contact Dr. Maxim Yulikov at Show e-mail.